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https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628162546859-E5UYSPPA9O8QBON5N8EP/Gallery%2BPhoto%2B1.jpg People 2018 Rabeh Lab https://www.rabehlab.com/home daily 1.0 2021-08-19 https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1629191057116-S08Q0NVMWWPQ7ASR9828/unsplash-image-pwcKF7L4-no.jpg Home - Our Research Learn more about the three areas of research carried out at SBBC. https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628162546859-E5UYSPPA9O8QBON5N8EP/Gallery%2BPhoto%2B1.jpg Home - Our Team Get to know the people who make our research and publications a reality, including Principal Investigator Wael Rabeh, PhD. https://www.rabehlab.com/calorimetry daily 0.75 2021-08-17 https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1629190587324-FI849SK5S0UAXCZH5WWC/DSC Calorimetry - Differential Scanning Calorimetry (DSC) The Nano-DSC from TA Instruments is used for the direct measurement of the amount of heat absorbed or released by the unfolding of proteins at a specific temperature ramp rate. The temperature difference between the sample and reference cells is used to calculate the thermodynamic parameters of the unfolding protein. https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628507458915-YE4DMRSY57KG9QBH0A1J/PCR Calorimetry - Real-Time PCR The Mx3005P QPCR system from Agilent is ideal for a wide variety of applications. One of the main applications for our laboratory is the high throughput screening of proteins’ thermodynamic stability using Sypro-Orange as a reporter dye. https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628507068432-0DU7PFQB9MXJC9H1ULFT/ITC Calorimetry - Isothermal Titration Calorimetry (ITC) The Nano-ITC from TA Instruments is used to directly measure the heat released or absorbed by biomolecular binding events. The data is used for the determination of the thermodynamic binding parameters, including the binding constants (Kb), reaction stoichiometry (n), enthalpy (ΔH), and entropy (ΔS). https://www.rabehlab.com/kristos daily 0.75 2021-08-11 https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628674719017-AGVFIVOT11XLS7F2500L/Kristos%252BPortrait.jpg Kristos Biography - Kristos Baffour Kristos is an undergraduate student of NYUAD majoring in Chemistry. He comes from Kumasi in Ghana and enjoys playing football. He joined Prof. Rabeh’s lab in his sophomore year as a research assistant, where he pursued his capstone project in the discovery of inhibitors of human hexokinase 2. https://www.rabehlab.com/protein-expression-purification daily 0.75 2021-08-18 https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1629276391270-1TTCMNK3QUSYZRPLFF1H/Avanti.jpg Protein Expression - High-Speed Centrifuges https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628534339466-POUCTAC9XV62ZA7K95MT/IMG_1395.JPG Protein Expression - Shaker Incubators A temperature controlled biochemical instrument combining incubation and shaking functions. https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628509170981-UGK43GK1SFXA84L1WHCM/IMG_1435.JPG Protein Expression - Gel Imaging System The ChemiDoc XRS+ System from Bio-Rad is a CCD high-resolution and high-sensitivity imaging system with fluorescence, colorimetry, densitometry, chemiluminescence, and chemifluorescence capabilities. https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628534041402-JSYW9EDVQY3DPAFSE6VR/Protein+Columns Protein Expression - Protein Columns Column Chromatography is a preparative technique used to purify compounds depending on their polarity or hydrophobicity. In column chromatography, a mixture of molecules is separated based on their differentials partitioning between a mobile phase and a stationary phase. https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628509070858-X7T0Q5OXYVGU50FB8FRO/FPLC Protein Expression - Fast Protein Liquid Chromatography (FPLC) The ÄKTA explorer 100 Air from GE Healthcare Life Sciences is an FPLC system used for the purification of protein samples using low- and high-throughput applications. https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628533903024-Y693QPSVZVA2T6FVEUSN/ULP Protein Expression - Ultrasonic Liquid Processors The VCX 130 and VCX 750 ultrasonic processors from SONICS are liquid processors for protein extraction from different cell cultures. https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1629190760874-4V1MHZF1Z0QEQTOMX1LC/LEX%2BBioreactor Protein Expression - LEX Bioreactor Epiphyte3's LEX ("Large-scale EXpression") bioreactor technology was developed at the Structural Genomics Consortium as an efficient, high-throughput method for growing E. coli cultures for protein expression. https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628534227985-PAX0MREEG6SDJY9MMJYH/IMG_1521.JPG Protein Expression - High-Speed Centrifuges used to harvest microorganisms, viruses, mitochondria, lysosomes, peroxisomes and intact tubular Golgi membranes. The majority of the simple pelleting tasks are carried out in fixed angle rotors. https://www.rabehlab.com/covid19 daily 0.75 2021-08-10 https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628606921783-OEN83WE73GABH132TSNP/unsplash-image-EDLcv5N4suo.jpg COVID-19 - SARS-CoV-2 COVID-19 has spread globally and caused an unprecedented global health pandemic. The discovery of therapeutics that can inhibit the progression of the SARS-CoV-2 will ensure a strong control over the spread of the virus. Our lab aims to biochemically and biophysically characterize the two proteases (3CLpro and PLpro) for the discovery and development of antiviral therapeutics against COVID-19. The proteases are important for the production of new virus particles by releasing functional proteins from the main virus polypeptides. https://www.rabehlab.com/adrian daily 0.75 2021-08-11 https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628674208857-NE5P4T5ZSKML8NNTA3HT/Adrian%2BPortrait.jpg Adrian Biography - Adrian Villanueva Adrian is part of the NYU Abu Dhabi undergraduate Class of 2022. He is from the Philippines but grew up in Abu Dhabi, UAE. He joined Professor Rabeh during the summer of his freshman year and was involved in different biochemical characterization of different enzymes. He will pursue his capstone project in the Structural Biology and Biophysical Chemistry Lab. https://www.rabehlab.com/cancer-metabolism daily 0.75 2021-08-10 https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628606028072-LJKHG95J85O61T8V79XE/unsplash-image-sIqWYiNLiJU.jpg Cancer Metabolism - Cancer Metabolism Glucose consumption has been shown to increase dramatically in cancer cells compared to normal tissues. The elevated glucose consumption is important to support the high cell proliferation rate observed in cancer compared to normal tissue. The specific inhibition of glucose metabolism in cancer will make an important strategy for the identification of new and safe classes of anticancer therapeutics with low side effects. https://www.rabehlab.com/hdxms daily 0.75 2021-08-09 https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/5298369a-441f-42c3-91cb-928dc311e0dd/DSC00866.JPG HDX-MS https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/fbbef37d-4dc6-4daa-85c6-c501d3b7b88f/DSC00857.JPG HDX-MS https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/4e11d6aa-9dc5-49a6-84ce-0210cae85ee2/1_Impact%2BII_MS_Bruker.jpg HDX-MS https://www.rabehlab.com/spectroscopy daily 0.75 2021-08-17 https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628507753520-W255YGAZB7X7JN753L20/CD+Spectrometer Spectroscopy - CD (Circular Dichroism) Spectrometer Chirascan-plus from Applied Photophysics is a CD spectrometer with a fast scanning rate and high sensitivity. It is used for the direct probing of proteins’ secondary structure or conformational changes. https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628508191942-0AT208DFWU2CF4RILC6S/SFS Spectroscopy - Stopped-Flow Spectrometer The SX20 stopped-flow spectrometer from Applied Photophysics is used for the characterization of enzymes’ fast reaction mechanisms on the millisecond scale. https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628507987269-J5XZFKKSDTAB0CBL2VEH/Microplate+Readers Spectroscopy - Microplate Readers The Spark from TECAN and Synergy H1 from BioTek are multimode microplate readers with capabilities to measure absorbance, fluorescence, and luminescence. https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628508407543-2FZZL9HM9DBJN0B5UFGH/IMG_1407.JPG Spectroscopy - UV-Vis Absorption Spectrometer The UV-2700 from Shimadzu is a double beam UV-visible spectrophotometer with variable sub-nanometer bandwidths and a wavelength range of 220-1400 nm. https://www.rabehlab.com/bioluminescence daily 0.75 2021-08-17 https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1629189896329-2TPDVUXEA2PAMSRRR6MN/Railroad+Worm Bioluminescence - Bioluminescence The bioluminescent light emitted by fireflies has dazzled scientists for centuries, including the mechanism of the light emission of different colors from the same chemical reaction. Luciferase enzymes are at the core of this natural phenomenon with energy transduction for the conversion of the chemical energy stored within the ground-state of the substrate (luciferin) to an excited, emissive state of the product (oxyluciferin). Understanding the mechanism for the stimulation of different colors of light is important for the advancement of different applications including in vivo imaging, monitoring of cell proliferation, studies into protein folding and secretion, and other environmental research and food quality control applications. https://www.rabehlab.com/juliana daily 0.75 2021-08-11 https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628674452075-AWZ9DOPAK0W4KIUSH709/Juliana%2BPortrait.jpg Juliana Biography - Juliana Ferreira Dr. Juliana Conrado Ferreira obtained her Bachelors in Biology from the University of Mogi das Cruzes, Brazil. She then went on to do Masters and Ph.D. in Biochemistry from the Federal University of Sao Paulo, Brazil. Before joining the SBBC laboratory at NYU Abu Dhabi in 2016, Dr. Ferreira was a postdoctoral fellow at the Federal University of ABC in Santo Andre, SP, Brazil. Currently, Dr. Ferreira is characterizing enzymes important in cancer metabolism and COVID-19 for the discovery of new therapeutics. https://www.rabehlab.com/xray-crystallography-automation daily 0.75 2021-08-17 https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628534588986-94ZJ1AFZLKKPMOTQGY8G/IMG_1576.JPG X-ray Crystallography - Automated Liquid Handling Platform The Bravo automated liquid handling platform from Agilent Technologies is utilized in high-throughput experimental analysis for the screening of new lead compounds as drug targets or for the custom setup of protein crystallization screens. https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628535074521-80E14EQ8L350L73JQJPY/IMG_20150309_131410.jpg X-ray Crystallography - Protein Crystallization Robot The HoneyBee X8 from Digilab is a high speed protein crystallization robot with eight channels for nanoliter dispensing volumes. Used for the fast and accurate setup of protein’s crystallization plates and for the determination of proteins’ tertiary structures using X-ray crystallography. https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628534940042-F8J40EDA779921Z2WZNP/IMG_1538.JPG X-ray Crystallography - Liquid Dispenser The CERTUS FLEX Micro Dispenser from Gyger is a microdisper system with microliter dispensing volumes. https://www.rabehlab.com/cameron daily 0.75 2021-08-19 https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/1628674564676-9GB9CL6J2TK7UY51Z04O/Cameron%2BPortrait.jpg Cameron Biography - Cameron Lee Shetler Cameron Shetler received her Bachelors of Science in Chemistry from New York University Shanghai in 2021. During her year-long study abroad at NYU Abu Dhabi, she worked in Rabeh's lab on hexokinase 2, a glycolytic enzyme important in cancer metabolism. After graduating, she returned to the SBBC laboratory at NYU Abu Dhabi to study COVID-19 proteases. https://www.rabehlab.com/lina-biography daily 0.75 2024-08-31 https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/c3987268-ba88-4d50-a9e8-9b4965c16568/1000030767.jpg Lina Biography - Lina Lee Lina Lee is a Chemistry major with a deep interest in biochemistry. She is currently working in Rabeh’s Lab, where she is gaining hands-on experience in the development of anti-cancer therapeutics. Lina’s research is focused on reducing the glycolytic rate in cancer for the discovery of small molecules that can reduce cancer growth. In addition, Lina is co-writing a review paper that explores proteins’ oligomeric states as an innovative drug discovery strategy. Lina aspires to continue her studies and research in biochemistry, with the ultimate aim of contributing to the development of more effective and safer therapeutic options for patients. https://www.rabehlab.com/samar daily 0.75 2024-08-31 https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/de7705ec-451f-40fb-8bbc-e4dd46c5948b/Samar.jpg Samar Biography - Samar Fadl Samar received her B.Sc. with Honors from Alexandria University, Egypt. She was awarded the Mo Ibrahim Fellowship for Nubian Students and obtained her Master of Science in Chemistry with Specialization in Food Chemistry from the American University in Cairo, Egypt. Samar research aim in the Rabeh lab for the discovery of new molecules against cancer and different corona viruses for the development of new and safe therapeutics. Samar has contributed substantially for the research of Rabeh lab as well as for the teaching of the biochemistry lab course at NYUAD. https://www.rabehlab.com/tariro-biography daily 0.75 2024-09-09 https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/116390ac-5a29-4f8c-a3ef-d9a57072b729/Tariro+Gurudza+headshot.jpg Tariro Biography - Tariro Gurudza Tariro Gurudza is a BioEngineering student at NYU Abu Dhabi, where she has developed expertise in protein purification, cell culturing, and biochemical assay development. As a Research Assistant in the Structural Biology and Biophysical Laboratory, she successfully cultured and purified proteins, conducted enzyme kinetics studies, and contributed to the characterization of proteins using advanced techniques. Her contributions to the study of 3C-like proteases in SARS-CoV-2 have also been recognized through her co-authorship of a peer-reviewed publication in Bioscience Reports. Tariro is interested in Protein Engineering and has a passion for Cancer therapeutic development. Tariro is eager to apply her skills to Pharmaceutical research and innovative biotech solutions. https://www.rabehlab.com/jandos-biography daily 0.75 2024-09-13 https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/661ed638-9129-4562-8651-09f5aef511ef/IMG_6320.jpg Jandos Biography - Jandos Shegenov Jandos is an undergraduate senior capstone student majoring in Chemistry. His research focuses on studying the effects of mutation of the beta-clasp of the human Ketohexokinase (KHK), an enzyme responsible for the metabolism of fructose. Jando’s Capstone project aims to characterize the effect of the beta-clasp on the function and stability of KHK, which will eventually contribute to the study of the role of the beta-clasp in the ribokinase enzyme families. He aspires to continue his studies in Biochemistry and/or Chemical Biology: "I believe that the SBBC Lab is an excellent team of scientists that prepares you to face all the challenges of continuing studies in the area of biochemistry while also cultivating rewarding research experience fulfilled with many biophysical and biochemical techniques.” https://www.rabehlab.com/roaa-biography daily 0.75 2025-01-29 https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/ab8ae3c3-dca6-4f7b-b7d6-9f537dae2956/Screenshot+2025-01-29+at+10.34.06%E2%80%AFAM.png Roaa Mahmoud - Roaa Mahmoud Dr. Roaa Mahmoud earned her Bachelor's degree in Chemistry from the American University of Sharjah before pursuing her Ph.D. in Chemistry at Virginia Commonwealth University (VCU) in Richmond, Virginia, USA, starting in 2019. During her doctoral research in the Dhakal Lab, she focused on characterizing DNA Holliday junctions and investigating their interactions with DNA damage repair proteins. Upon completing her Ph.D. in late 2024, Dr. Mahmoud began her postdoctoral training in the Structural Biology and Biochemistry Core (SBBC) Lab at NYU Abu Dhabi under the supervision of Prof. Wael Rabeh. Her research explores the biophysical and biochemical properties of various enzymes, with a particular emphasis on luciferase enzymes, which are key to the bioluminescence observed in fireflies and beetles. Through her work, she aims to deepen our understanding of enzyme function and structure, contributing to advancements in biochemistry and molecular biology. https://www.rabehlab.com/angela-biography daily 0.75 2025-01-30 https://images.squarespace-cdn.com/content/v1/5f5d2b1386473f345eecd2d2/c7470f43-ff01-4a91-9019-5d0aa104fe78/Angila.jpg Angela Biography - Angela Noh Angela is an undergraduate student majoring in chemistry. Her capstone project in the SBBC lab focuses on studying the enzymatic activity and stability of 3-chymotrypsin-like protease (3CLpro) in various coronaviruses at different pH conditions. The ultimate goal of this project is to develop a pH profile to verify the chemical mechanism of 3CLpro in these coronaviruses. Angela is also co-writing a review paper that explores proteins’ oligomeric states as an innovative drug discovery strategy. She enjoys applying biochemical techniques to uncover the molecular mechanisms underlying diseases and potential therapeutic interventions. She is particularly interested in translating research findings into clinical applications, with the goal of developing treatments that can ultimately benefit patients.